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Functional control of gastrin releasing peptide (GRP) mRNA in rat stomach
Author(s) -
Dimaline R.,
Sandvik A.K.,
Barclay G.,
Dockray G.J.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80259-j
Subject(s) - gastrin releasing peptide , stomach , gastrin , antrum , messenger rna , neuropeptide , medicine , northern blot , endocrinology , omeprazole , western blot , g cell , biology , gastric acid , peptide , chemistry , secretion , biochemistry , bombesin , gene , receptor
The gastric factors controlling abundance of mRNA encoding the important neuropeptide, gastrin releasing peptide (GRP) in rat stomach, were examined by Northern and slot blot analysis. Withdrawal of food increased antral GRP mRNA, as did treatment of fed rats with the acid inhibitory drug, omeprazole. There was no change in GRP mRNA abundance in gastric corpus. The data indicate functionally distinct populations of GRP neurons in different regions of the stomach, and control of antral neuropeptide biosynthesis by the gastric luminal contents.