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Interaction of cholesterol‐conjugated alkylating oligonucleotide derivatives with cellular biopolymers
Author(s) -
Ryte A.S.,
Karamyshev V.N.,
Nechaeva M.V.,
Guskova Z.V.,
Ivanova E.M.,
Zarytova V.F.,
Vlassov V.V.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80229-a
Subject(s) - conjugated system , oligonucleotide , chemistry , cholesterol , biochemistry , combinatorial chemistry , dna , organic chemistry , polymer
Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2‐chloroethylamino group at the 3′‐end and a cholesterol residue at the 5′‐terminal phosphate. These compounds are readily taken up by cells and react with cellular DNA, RNA and some proteins which may play a role in delivery of the compounds into cells.