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Inhibition of rat liver microsomal fatty acid chain elongation by gemfibrozil in vitro
Author(s) -
Sánchez R.M.,
Viñals M.,
Alegret M.,
Vázquez M.,
Adzet T.,
Merlos M.,
Laguna J.C.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80170-l
Subject(s) - gemfibrozil , microsome , chemistry , elongation , in vitro , biochemistry , polyunsaturated fatty acid , coenzyme a , limiting , cofactor , enzyme , fatty acid , reductase , cholesterol , mechanical engineering , materials science , metallurgy , ultimate tensile strength , engineering
Gemfibrozil, a hypolipidemic drug mainly used in the treatment of hypertriglyceridemic states, strongly inhibits the rat hepatic microsomal fatty acid chain elongation system in vitro. The inhibition is independent on the reducing cofactor used in the assay. Furthermore, gemfibrozil seems to act by inhibiting the rate‐limiting step of the elongation process, the condensing reaction, without discriminating among the proposed three different condensing enzymes, devoted to condensation of saturated, mono‐unsaturated and polyunsaturated acyl‐CoA substrates.