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Time course of K + current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body Effects of carbon monoxide
Author(s) -
López-López J.R.,
González C.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80126-2
Subject(s) - carotid body , chemoreceptor , carbon monoxide , oxygen , chemistry , biophysics , rabbit (cipher) , current (fluid) , nuclear chemistry , electrophysiology , biochemistry , medicine , biology , organic chemistry , catalysis , receptor , statistics , mathematics , electrical engineering , engineering
K + currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO 2 in the bathing solution. Bath application of a hypoxic TTX‐containing solution revealed that inhibition of K + current by low pO 2 , proceeds faster than TTX inhibition of Na + currents, the apparent t ½ being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K + currents by approx. 70%.