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Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells
Author(s) -
Najid A.,
Simon A.,
Cook J.,
Chable-Rabinovitch H.,
Delage C.,
Chulia A.J.,
Rigaud M.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80117-y
Subject(s) - hl60 , lipoxygenase , ursolic acid , chemistry , cyclooxygenase , thp1 cell line , platelet , leukotriene , biochemistry , cell culture , biology , enzyme , immunology , in vitro , chromatography , genetics , asthma
A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone‐extract of heather flowers ( Calluna vulgaris ) wllich could help explain the anti‐inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 μM, blocks arachidonate metabolism.