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Endogenous Xenopus ‐oocyte Ca‐channels are regulated by protein kinases A and C
Author(s) -
Bourinet E.,
Fournier F.,
Nargeot J.,
Charnet P.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80087-w
Subject(s) - xenopus , calcium , t type calcium channel , microbiology and biotechnology , oocyte , endogeny , voltage dependent calcium channel , divalent , kinase , chemistry , r type calcium channel , protein kinase c , n type calcium channel , calcium channel , calcium in biology , biophysics , intracellular , biology , biochemistry , embryo , organic chemistry , gene
Calcium entry into Xenopus oocyte occurs mainly through voltage‐dependent calcium channels. These channels were characterized as belonging to a particular type of calcium channel insensitive to dihydropyridines, ω‐conotoxin, and Agelenopsis aperta venom, but blocked by divalent cations (Co, Cd, Ni). Intracellular injection of cAMP, or bath application of phorbol ester, induced a marked increase in calcium current amplitude and a slowing of the inactivation time‐course. Despite their different pharmacology, endogenous calcium channels, like cardiac or neuronal calcium channels, could be thus regulated by protein kinases A and C.