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p23, a novel mammalian nucleic acid‐binding protein with homology to the yeast ribosomal protein YL43
Author(s) -
Østvold Anne Carine,
Hullstein Ingunn,
Sletten Knut
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80061-k
Subject(s) - nucleic acid , yeast , biochemistry , homology (biology) , ribosomal protein , ribosomal rna , chemistry , biology , ribosome , microbiology and biotechnology , amino acid , rna , gene
When separating perchloric acid‐soluble proteins from cell cultures and tissues by chromatography on single stranded DNA agarose columns, a novel mammalian protein with extreme affinity for DNA was isolated. Cellular localization, amino acid composition and the N‐terminal sequence suggest that the protein is a ribosomal protein with extensive sequence homology to the ribosomal protein, YL43, from Saccharomyces cerevisiae .