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Thromboxane receptor stimulation inhibits adenylate cyclase and reduces cyclic AMP‐mediated inhibition of ADP‐evoked responses in fura‐2‐loaded human platelets
Author(s) -
Sage Stewart O.,
Heemskerk Johan W.M.
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80056-m
Subject(s) - forskolin , adenylate kinase , cyclase , stimulation , endocrinology , medicine , thromboxane a2 , platelet , thromboxane , chemistry , thromboxane receptor , prostaglandin e1 , prostaglandin , receptor , prostaglandin e , intracellular , biology , biochemistry
Stimulation of human platelets with the thromboxane A 2 analogue, U46619, after treatment with prostaglandin E 1 or forskolin, reduced the inhibition of ADP‐evoked Mn 2+ influx and the release of Ca 2+ from intracellular stores, U46619 decreased the elevated concentration of 3′, 5′‐cyclic AMP in platelets that were pretreated with prostaglandin E 1 . These results suggest that occupation of prostaglandin H 2 /thromboxane A 2 receptors. like those for other agonists, inhibits adenylate cyclase activity, which can contribute to the promotion of platelet activation.