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A new cyclopyrophosphate as a bacterial antistressor?
Author(s) -
Ostrovsky Dmitry,
Shipanova Irina,
Sibeldina Lily,
Shashkov Alexandr,
Kharatian Elena,
Malyarova Irina,
Tantsyrev Georgy
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80045-i
Subject(s) - bacteria , chemistry , pyrophosphate , brevibacterium , bacterial cell structure , biochemistry , biology , microorganism , enzyme , genetics
In a number of bacteria an unusual glycosyl pyrophosphate ( 31 P NMR signal chemical shift at about −15 ppm) was detected when the cells were subjected to oxidative stress. This substance from Brevibacterium ammoniagenes has now been identified as 2‐methyl‐butan‐1,2,3,4‐tetraol‐2,4‐cyclopyrophosphate, which is accumulated in the cell under certain conditions in concentrations of about 50 mM. It is now suggested that this compound is the long sought after bacterial antistressor.