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Minor‐groove width and accessibility in B‐DNA drug and protein complexes
Author(s) -
Neidle Stephen
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80030-k
Subject(s) - minor groove , minor (academic) , groove (engineering) , dna , chemistry , biochemistry , materials science , art , humanities , metallurgy
A new definition is presented for minor‐groove width in double‐helical B‐DNA structures. This uses interstrand H4′…H5′ rather than P…P distances. It is shown by examination of various oligonucleotide crystal structures that these H4′…H5′ distances are a sensitive measure of minor‐groove drug and protein binding, since these hydrogen atoms are in direct non‐bonded contact with such bound ligands.