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Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum
Author(s) -
Hayakawa Taro,
Yamashita Kyoko,
Tanzawa Kazuhiko,
Uchijima Ekuko,
Iwata Kazushi
Publication year - 1992
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(92)80015-9
Subject(s) - matrix metalloproteinase , growth factor , cell growth , microbiology and biotechnology , inhibitory postsynaptic potential , tissue inhibitor of metalloproteinase , chemistry , cell culture , in vitro , endocrinology , biology , biochemistry , receptor , genetics
Human tissue inhibitor of metalloproteinases‐1 (TIMP‐1), but not TIMP‐2, has potent growth‐promoting activity for a wide range of human and bovine cells, TIMP‐1 seems to be a new cell‐growth factor in serum and to stimulate the cells independently of its inhibitory activity.