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Inhibition of protein tyrosine phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts
Author(s) -
Monteiro Hugo P.,
Ivaschenko Yuri,
Fischer Roland,
Stern Arnold
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81405-w
Subject(s) - epidermal growth factor , protein tyrosine phosphatase , chemistry , tyrosine , phosphatase , biochemistry , microbiology and biotechnology , biology , phosphorylation , receptor
Diamide (azodicarboxylic acid bis(dimethylamide)) inhibits protein tyrosine phosphatase activity in fibroblasts without altering protein tyrosine kinase activity associated with the epidermal growth factor receptor. The loss of protein tyrosine phosphatase activity caused by diamide is reversed by 2‐mercaptoethanol or epidermal growth factor.