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Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi
Author(s) -
Rojas M.Verónica,
Galanti Norbel
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81377-k
Subject(s) - trypanosoma cruzi , dna methylation , methylation , dna , cell growth , biology , chemistry , microbiology and biotechnology , biochemistry , gene , gene expression , parasite hosting , world wide web , computer science
5‐Azacytidine treatment of T. cruzi epimastigotes in culture induces active cell proliferation. This effect was detected as an increase in the cell number and [ 3 H‐methyl]thymidine incorporation into DNA. 5‐Azacytidine does not alter other metabolic parameters. We have previously demonstrated that 5‐azacytidine induces DNA hypomethylation in T. cruzi . Accordingly, we suggest that this chemical modification may be related to the control of T. cruzi cell division.