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(HX) n repeats: a pH‐controlled protein—protein interaction motif of eukaryotic transcription factors?
Author(s) -
Janknecht Ralf,
Sander Chris,
Pongs Olaf
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81369-j
Subject(s) - motif (music) , transcription (linguistics) , chemistry , genetics , microbiology and biotechnology , biology , physics , philosophy , linguistics , acoustics
A characteristic sequence repeat of type His‐X, repeated several times in a row, is present in several eukaryotic transcription factors, e.g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX) n repeats can mediate interaction between transcription factors in a pH‐controlled fashion.