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Bovine lens capsule basement membrane collagen exerts a negative priming on polymorphonuclear neutrophils
Author(s) -
Monboisse Jean-Claude,
Bellon Georges,
Perreau Corinne,
Garnotel Roselyne,
Borel Jacques-Paul
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81358-f
Subject(s) - basement membrane , capsule , priming (agriculture) , chemistry , lens (geology) , microbiology and biotechnology , biophysics , immunology , biology , botany , germination , paleontology
After a 30 min contact between purified bovine lens capsule basement membrane type IV collagen and polymorphonuclear neutrophils, stimulation of these cells by N‐formyl‐methionyl‐leucyl‐phenylalanine, PMA or type I collagen releases a decreased amount of superoxide ions (negative priming). The inhibitory activity is located in the NCl domain. On the other hand, after pepsin digestion, the helical part of type IV collagen determines a positive priming of neutrophils.