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Immunological identification and sequence characterization of a peptide derived from the processing of neuroendocrine protein 7B2
Author(s) -
Paquet Luc,
Rondeau Normand,
Seidah Nabil G.,
Lazure Claude,
Chrétien Michel,
Mbikay Majambu
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81334-5
Subject(s) - peptide , biology , peptide sequence , enteroendocrine cell , microbiology and biotechnology , biochemistry , endocrine system , hormone , gene
A newly raised antiserum against the C‐terminal region of neuroendocrine protein 7B2 was used to purify a novel peptide from the culture media of the mouse corticotroph cell line AtT‐20. Based on partial sequencing, this peptide, which we call Cter‐7B2, begins at Ser 156 and appears to result from the cleavage of pro7B2 after a five‐basic‐residue sequence. Thus, 7B2 processing may contribute to the diversity of peptides found in neuronal and endocrine cells.