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Histone H1 and the regulation of transcription by nuclear receptors
Author(s) -
Oikarinen Jouko
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81330-b
Subject(s) - nucleosome , histone h1 , microbiology and biotechnology , chromatin , histone , histone code , nuclear receptor , effector , biology , chemistry , transcription factor , dna , biochemistry , gene
Histone H1 is a eukaryotic repressor which recognizes specific DNA structures, and nucleotides regulate its interaction with DNA. Since their mode of action may be considered similar to that observed in the case of plasma membrane GTPases, H1 may be regarded as an ATP/GTPase involved in the action of nuclear receptors. A hypothesis is put forward here to suggest that transcriptional activators CTF/NF‐I and AP‐1 ( fos/jun ), for example, are effectors for H1. H1 and CTF/NF‐I may be members of a stimulatory regulatory cascade for nuclear receptor action that ends with selective activation of chromatin through histone modification and the disruption or a more subtle structural change of a specific nucleosome, while an opposite effect may be obtained through modification of fos/jun by H1.