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Antiviral activity of some natural and synthetic sugar analogues
Author(s) -
Huang Richard,
Dietsch Ellen,
Lockhof Oswald,
Schüller Matthias,
Reutter Werner
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81283-e
Subject(s) - sugar , virus , strain (injury) , derivatization , cytopathic effect , chemistry , biochemistry , virology , stereochemistry , microbiology and biotechnology , biology , organic chemistry , high performance liquid chromatography , anatomy
A number of natural and synthetic sugar analogues have been tested for their antiviral activity, using an influenza virus strain as a model. Hemagglutinating titres (HA) and cytopathic effect (CPE) were surveyed to estimate the virus production. It was found that introduction of the benzyl group into these sugars generally causes them to become antivirally active. Substitution with methyl, acetyl, uridyl and thiocyanyl groups or derivatization with azido, isopropylidene and benzylidene groups were without effect. All sugars containing the 2‐deoxy‐2‐acetamido group were inactive.