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8–37 h‐CGRP antagonizes actions of amylin on carbohydrate metabolism in vitro and in vivo
Author(s) -
Wang Ming-Wei,
Young Andrew A.,
Rink Timothy J.,
Cooper Garth J.S.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81282-d
Subject(s) - amylin , calcitonin gene related peptide , medicine , endocrinology , receptor , in vivo , chemistry , calcitonin , soleus muscle , in vitro , antagonist , calcitonin receptor , insulin , skeletal muscle , biology , neuropeptide , biochemistry , microbiology and biotechnology , islet
8–37 hCGRP is a potent antagonist at calcitonin gene‐related peptide (CGRP) liver membrane receptors; it also blocks vasodilator actions of CGRP and the related peptide, amylin, in intact rats. We now report that 8–37 hCGRP antagonizes amylin inhibition of insulin‐stimulated labelled glucose uptake into isolated rat soleus muscle, and inhibits amylin‐evoked elevation of plasma lactate and glucose in fasted anaesthetized rats. The different relative potencies of the 3 ligands (amylin, CGRP, 8–37 hCGRP) on the liver receptor and on the soleus muscle point to distinct CGRP receptors in liver membranes and amylin receptors on muscle cells.