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POMC gene expression in mouse and hamster melanoma cells
Author(s) -
Slominski Andrzej
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81274-c
Subject(s) - hamster , complementary dna , messenger rna , gene expression , phenotype , microbiology and biotechnology , gene , biology , melanoma , cell culture , cancer research , genetics
Expression of mRNA hybridizable to murine POMC cDNA, and immunoreactivity specific for POMC derived peptide, β‐endorphin, are reported for the first time in one murine and two hamster melanoma lines. The apparent sizes of POMC mRNA transcript were 3.5, 1.5 and 1 kb. It is suggested that POMC gene expression may be involved in the autoregulation of the melanoma phenotype at the cellular and tissue levels.