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Heterogeneity in human soluble guanylate cyclase due to alternative splicing
Author(s) -
Chhajlani Vijay,
Frändberg Per-Anders,
Ahlner Johan,
Axelsson Krister L.,
Wikberg Jarl E.S.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81248-7
Subject(s) - gucy1a3 , gucy1b3 , guanylate cyclase , protein subunit , gucy2d , guanylate cyclase 2c , biochemistry , chemistry , enzyme , rna splicing , alternative splicing , cyclase , microbiology and biotechnology , biology , gene , messenger rna , rna
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC‐1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC‐2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC‐2 is formed due to alternative splicing.