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Inactivation of human plasma C1‐inhibitor by human PMN leucocyte matrix metalloproteinases
Author(s) -
Knäuper Vera,
Triebel Susanne,
Reinke Heinz,
Tschesche Harald
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81235-z
Subject(s) - gelatinase , matrix metalloproteinase , human plasma , chemistry , collagenase , gelatinase a , cleavage (geology) , biochemistry , microbiology and biotechnology , enzyme , biology , paleontology , chromatography , fracture (geology)
Highly purified human polymorphonuclear (PMN) leucocyte matrix metalloproteinases, collagenase and gelatinase, cleaved human plasma C1‐inhibitor at the carboxyl site of Ala 439 (P 6 ). This led to a concomitant loss of C1‐inhibitor activity. An additional cleavage site at the carboxyl site of Ser 441 (P 4 ), was observed during PMN leucocyte gelatinase‐induced inactivation, and a minor fragment of the plasma C1‐inhibitor was generated.