Nitromethylene actions on in situ and expressed insect nicotinic acetylcholine receptors | Zendy

Leech C.A. | Zendy; Jewess P. | Zendy; Marshall J. | Zendy; Sattelle D.B. | Zendy

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Nitromethylene actions on in situ and expressed insect nicotinic acetylcholine receptors

Author(s) -

Leech C.A.,

Jewess P.,

Marshall J.,

Sattelle D.B.

Publication year - 1991

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/0014-5793(91)81233-x

Subject(s) - nicotinic agonist , acetylcholine receptor , ganglion type nicotinic receptor , schistocerca , acetylcholine , receptor , housefly , agonist , chemistry , nicotinic acetylcholine receptor , biochemistry , biology , pharmacology , biophysics , locust , botany , musca , larva

Single channel recordings from dissociated housefly ( Musca domestica ) neurons show that a novel type of nitromethylene insecticide, 2(nitromethylene)tetrahydro‐1,3‐thiazine (NMTHT) gates a channel, the conductance and open time histogram of which resemble those obtained when acetylcholine is the agonist. Injection into Xenopus oocytes of a locust ( Schistocerca gregaria ) α‐subunit mRNA results in the expression of functional nicotinic receptors sensitive to NMTHT. Control oocytes injected with distilled water are insensitive to the same concentration of this compound. Thus NMTHT exhibits agonist actions at both in situ and expressed insect nicotinic receptors, and one site of action of this compound is on an insect nicotinic receptor α‐subunit.

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