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TPA‐induced activation of MAP kinase
Author(s) -
Adams Peter D.,
Parker Peter J.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81230-6
Subject(s) - mitogen activated protein kinase , phosphorylation , threonine , mitogen activated protein kinase kinase , map2k7 , chemistry , map kinase kinase kinase , kinase , protein kinase a , tyrosine , biochemistry , tyrosine kinase , mapk14 , microbiology and biotechnology , cyclin dependent kinase 2 , biology , signal transduction , serine
Threonine and tyrosine residue phosphorylation of a 42 kDa protein identified as mitogen‐activated protein kinase (MAP kinase) was stimulated in extracts from TPA‐pretreated cells. It is further shown that TPA pretreatment leads to the enhancement of an activity that will induce reactivation of dephosphorylated/inactivated MAP kinase. This TPA‐induced activity induces the threonine and tyrosine phosphorylation of p42 in extracts from unstimulated cells.