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Bacterioferritins and ferritins are distantly related in evolution Conservation of ferroxidase‐centre residues
Author(s) -
Andrews S.C.,
Smith J.M.A.,
Yewdall S.J.,
Guest J.R.,
Harrison P.M.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81177-a
Subject(s) - ceruloplasmin , ferritin , structural similarity , biochemistry , metalloprotein , biology , peptide sequence , amino acid , chemistry , enzyme , gene
Iron‐storage proteins can be divided into two classes; the bacterioferritins and ferritins. In spite of many apparent structural and functional analogies, no significant amino acid sequence similarity has been detected previously. This report now reveals a distant evolutionary relationship between bacterioferritins and ferritins derived by ‘Profile Analysis’. Optimum alignment of bacterioferritin and ferritin sequences suggests that key residues of the ferroxidase centres of ferritins are conserved in bacterioferritins.