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Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin
Author(s) -
Martin-Nizard Françoise,
Houssaini Hayat Sqalli,
Lestavel-Delattre Sophie,
Duriez Patrick,
Fruchart Jean-Charles
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81167-7
Subject(s) - butylated hydroxytoluene , chemistry , endocrinology , secretion , medicine , low density lipoprotein , phorbol , macrophage , biochemistry , antioxidant , cholesterol , protein kinase c , in vitro , biology , signal transduction
This study attempted to determine if low density lipoproteins (LDL) induce the production of endothelins (ET) by human macrophages. Non‐protected LDL from macrophage induced oxidation (n‐LDL), copper‐oxidized LDL (Ox‐LDL), acetylated‐LDL (Ac‐LDL), butylated hydroxytoluene‐LDL (BHT‐LDL), BHT‐Ac‐LDL, polyinosinic acid (PiA, 1.5μg/ml), phorbol myristate acetate (PMA; 0.5 μM) and BHT alone (20 μM) were studied. The different compounds had the following potency to stimulate the ET secretion: PMA>Ox‐LDL>Ac‐LDL>n‐LDL>BHT‐LDL>PiA>PiA+Ac‐LDL>BHT. In conclusion, mod stimulated ET secretion by human macrophages.