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Amylin injection causes elevated plasma lactate and glucose in the rat
Author(s) -
Young Andrew A.,
Wang Ming-Wei,
Cooper Garth J.S.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81113-m
Subject(s) - glycogenolysis , medicine , endocrinology , amylin , gluconeogenesis , chemistry , glycogen , plasma glucose , blood lactate , insulin , metabolism , blood pressure , biology , islet , heart rate
Intravenous injections of 25.5 nmol rat amylin into fasted anesthetized rats caused a rapid increase in plasma lactate followed by an increase in plasma glucose; there was a transient fall in blood pressure. Subcutaneous injection of 25.5 nmol amylin also caused increases in lactate and glucose but did not change blood pressure. Similar responses were observed during somatostatin infusion and in the absence of changes in catecholamines. These results fit with a scheme in which amylin elicits muscle glycogenolysis, release of lactate, and increased hepatic gluconeogenesis due to increased supply of substrate.