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Regions in the promoter of the yeast FBP1 gene implicated in catabolite repression may bind the product of the regulatory gene MIG1
Author(s) -
Mercado Juan J.,
Vincent Olivier,
Gancedo Juana M.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81112-l
Subject(s) - catabolite repression , psychological repression , promoter , gene , biology , yeast , fed batch culture , gene product , regulation of gene expression , genetics , microbiology and biotechnology , biochemistry , gene expression , mutant , fermentation
We have identified in the promoter of the yeast FBP1 gene two sites able to bind nuclear proteins. These sites have a nucleotide sequence strongly similar to that of sites which bind the regulatory protein MIG1 in the promoters of GAL4 and SUC2 . Deletions performed in the FBP1 promoter showed that one of the sites contributes to catabolite repression of this gene. In the same promoter, another region was identified with a strong effect on the catabolite repression of FBP1 . In this region a sequence similar to the consensus for the binding site of the MIG1 protein was also present.