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Sphingosine and unsaturated fatty acids modulate the base exchange enzyme activities of rat brain membranes
Author(s) -
Kanfer J.N.,
McCartney D.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81104-g
Subject(s) - sphingosine , membrane , chemistry , enzyme , biochemistry , sphingolipid , base (topology) , receptor , mathematical analysis , mathematics
The base exchange enzymes catalyze the incorporation of L‐serine, ethanolamine and choline into their corresponding phospholipids. The L‐serine base enzyme activity was increased 120% by 0.1 mM sphingosine. There was a modest increase of the ethanolamine base exchange enzyme activity but the choline base exchange enzyme activity was unaffected. Na‐arachadonate, Na‐oleate and Na‐linolenate at 0.2 mM concentration increased the activity of the L‐serine and ethanolamine base exchange enzymes but inhibited the choline base exchange enzyme activity. A model is proposed suggesting that modulations of the L‐serine base exchange enzyme may participate in the regulation of the calcium phospholipid‐dependent protein kinase C.