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Activation of respiration and loss of thermodynamic control in hyperthyroidism Is it due to increased slipping in mitochondrial proton pumps?
Author(s) -
Luvisetto Siro,
Schmehl Ibolya,
Conti Elena,
Intravaia Elena,
Azzone Giovanni Felice
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81093-n
Subject(s) - conductance , slipping , proton , chemistry , proton pump , biophysics , respiration , mitochondrion , membrane potential , atpase , biochemistry , biology , anatomy , physics , condensed matter physics , mechanical engineering , quantum mechanics , engineering , enzyme
T 3 administration increases the extent of non‐linearity in the flow—force relationship between pump proton conductance and protonmotive force. The effect is present also at the ATPase proton pump. These effects are not accompanied by changes in passive proton conductance. Incubation of mitocondria at 45°C also causes an increased non‐linearity, accompanied by a partial increase of proton conductance. It appears that the increase of respiratory activity following T 3 administration is due to loss of thermodynamic control within or at the proton pumps, an effect which might be attributed to increased slipping.