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The protecting effect of L‐carnitine on Ca 2+ ‐loaded rat liver mitochondria
Author(s) -
Mokhova E.,
Arrigoni-Martelli E.,
Bellei M.,
Dedukhova V.,
Muscatello U.,
Starkov A.,
Bobyleva V.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81066-h
Subject(s) - carnitine , mitochondrion , respiration , endogeny , oxidative phosphorylation , stimulation , chemistry , biochemistry , medicine , endocrinology , biology , anatomy
It is shown that L‐carnitine strongly increases the ability of rat liver mitochondria to respond to the train of Ca 2+ additions by a transient stimulation of the State‐4 respiration rate. Such an effect requires ATP and the L‐carnitine efficiency strongly decreases when ATP is omitted, Oleate influences the mitochondria in a fashion opposite to that of L‐carnitine. The oleate effect is strongly diminished by L‐carnitine. Again, the L‐carnitine effect requires ATP, and D‐carnitine fails to substitute for L‐carnitine. It is suggested that L‐carnitine removes, in an ATP‐dependent manner, endogenous or added fatty acids, which are involved in oxidative damage of Ca 2+ ‐loaded mitochondria.