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Involvement of sapecin in embryonic cell proliferation of Sarcophaga peregrina (flesh fly)
Author(s) -
Komano Hiroto,
Homma Ko-ichi,
Natori Shunji
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81061-c
Subject(s) - flesh fly , flesh , embryonic stem cell , biology , microbiology and biotechnology , anatomy , botany , biochemistry , larva , horticulture , gene
Addition of antibodies against sapecin to the culture medium of NIH‐Sape‐4 cells derived from a Sarcophaga embryo greatly inhibited cell proliferation, whereas addition of sapecin stimulated cell proliferation. These results suggest that sapecin is involved in the proliferation of embryonic cells of Sarcophaga . Sapecin is known to have potent antibacterial activity, so it seems to have two different biological functions: i.e. protection against bacterial infection and stimulation of embryonic cell proliferation.