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A rat gene encoding heart 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase
Author(s) -
Darville Martine I.,
Chikri Mohamed,
Lebeau Etienne,
Hue Louis,
Rousseau Guy G.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81009-w
Subject(s) - fructose , phosphofructokinase 2 , gene , chemistry , fructose 1,6 bisphosphatase , biochemistry
There are at least 3 isozymes of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6‐bisphosphate. A 22‐kb rat gene that encodes the heart isozyme has been identified and compared with the 55‐kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N‐ and C‐termini in the 3 isozymes.