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A 64 kDa protein from Mycobacterium bovis BCG shares the same antigenic determinants with line 10 hepatoma cells and has anti‐line 10 tumor activity
Author(s) -
Ahsan C.R.,
Sasaki J.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81006-t
Subject(s) - antigen , mycobacterium bovis , kilodalton , strain (injury) , biology , cell culture , microbiology and biotechnology , guinea pig , epitope , chemistry , immunology , mycobacterium tuberculosis , tuberculosis , medicine , genetics , pathology , anatomy , endocrinology
A 64 kilodalton (kDa) surface protein was isolated from the water‐extracted materials from Mycobacterium bovis strain BCG, the determinants of which are antigenically shared by a 64 kDa major surface antigenic component of line 10 hepatoma cells. The 64 kDa protein showed anti‐line 10 tumor activity in pre‐immunized guinea pigs, and this suggests that the BCG 64 kDa protein is probably identical with the tumor specific antigen.