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Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor
Author(s) -
Takahashi Jun A.,
Fukumoto Manabu,
Kozai Yoshio,
Ito Nobuyuki,
Oda Yoshifumi,
Kikuchi Haruhiko,
Hatanaka Masakazu
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81004-r
Subject(s) - fibroblast growth factor , basic fibroblast growth factor , antibody , monoclonal antibody , cancer research , neutralizing antibody , receptor , carcinogenesis , hela , cancer cell , neutralization , microbiology and biotechnology , biology , cell , chemistry , growth factor , immunology , cancer , biochemistry , genetics
We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage‐dependent and anchorage‐independent growth of U‐87MG and T98G human glioblastoma cells and HeLa cells, all of which express both the basic FGF and the FGF remptor genes. In addition, the subcutaneous administration of this antibody significantly suppressed the tumor development or these tumor cells in nude mice. Therefore, basic FGF plays an important role in neoplastic growth of these cells. The neutralization or basic FGF will be effective in controlling the growth of tumors, such as glioblastoma and other cancer cells which bear basic FGF and FGF receptors.