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Developmental expression of G proteins that differentially modulate adenylyl cyclase activity in mouse brain
Author(s) -
Rius R.Adrian,
Streaty Richard A.,
Loh Y.Peng,
Klee Werner A.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)81001-o
Subject(s) - adenylyl cyclase , gs alpha subunit , adcy10 , adcy9 , g protein , activator (genetics) , endocrinology , medicine , cyclase , biology , camp dependent pathway , adcy6 , stimulation , chemistry , microbiology and biotechnology , biochemistry , gene , signal transduction
Changes in the relative abundance of the G protein α subunits were observed during early mouse development G sa was almost exclusively present as a large form (G s‐1 ) in prenatal brain. Postnatally with a substantial increase in Gpp[NH]p stimulated adenylyl cyclase activity, the small form (G ?? increased in amount while G s‐1 decreased. These results suggest that the G s‐1 may be the more effective cyclase activator and that changes in alternative splicing are developmentally regulated. G i1 and G o appeared before birth whereas Gi 2 , developed postnatally. Opiate stimulation of GTPase and inhibition of adenylyl cyclase were fully expressed prenatally.

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