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Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family
Author(s) -
Wittka Reilinde,
Stocker Martin,
Boheim Günther,
Pongs Olaf
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80972-6
Subject(s) - shaker , potassium channel , potassium , potassium channel blocker , chemistry , channel (broadcasting) , biophysics , basis (linear algebra) , biology , computer science , mathematics , telecommunications , physics , acoustics , organic chemistry , vibration , geometry
The two alternative carboxyl‐termini of Shaker K + channels strongly influence the rates of inactivation and of recovery from channel inactivation. We show that this distinct inactivation behaviour is due to an alanine/valine amino acid replacement within the Shaker carboxyl‐terminus at a site that occurs within the proposed membrane spanning segment S6.