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Effects of the lipase inhibitors, Triton WR‐1339 and tetrahydrolipstatin on the synthesis and secretion of lipids by rat hepatocytes
Author(s) -
Hermier Dominique,
Hales Paul,
Brindley David N.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80970-e
Subject(s) - lipase , secretion , intracellular , enzyme , biochemistry , chemistry , lipid metabolism , incubation , glyceride , triacylglycerol lipase , triton x 100 , metabolism , hepatocyte , biology , fatty acid , in vitro , pulmonary surfactant
The lipase inhibitors, Triton WR‐1339 and tetrahydrolipstatin, were incubated with rat hepatocytes. Triton WR‐1339 increased the recovery of triacylglycerol in the hepatocytes and incubation medium by 31% and 38%, respectively. Tetrahydrolipstatin decreased the accumulation of newly synthesized, and of total triacylglycerol in the medium. This compound might be useful in determining mechanisms involved in intracellular triacylglycerol metabolism and the secretion of very low density lipoproteins.