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Identification of a rat liver dipeptidyl aminopeptidase IV with a liver plasma membrane glycoprotein (gp110) A study using dipeptidyl aminopeptidase IV‐deficient rats
Author(s) -
Iwaki-Egawa Sachiko,
Watanabe Yasuhiro,
Fujimoto Yukio
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80966-7
Subject(s) - aminopeptidase , glycoprotein , membrane glycoproteins , dipeptidyl peptidase , biochemistry , complementary dna , microbiology and biotechnology , chemistry , peptide sequence , amino acid , biology , enzyme , gene , leucine
A rat liver plasma membrane glycoprotein, gp110, was compared with dipeptidyl aminopeptidase IV (DAP IV) by using Wistar rats (DAP IV‐positive rats) and Fischer 344 rats (DAP IV‐negative rats). Fischer rats also lacked gp110 and gp110 of Wistar rats had DAP IV activity. Furthermore, we showed that the C‐terminal sequence of gp110 was Ser‐Leu‐Arg, which was the same as the C‐terminal amino acid sequence deduced from the nucleotide sequence of the cDNA of DAP IV. According to these results, we concluded that gp110 was identical with DAP IV.