Premium
Paraoxonase prevents accumulation of lipoperoxides in low‐density lipoprotein
Author(s) -
Mackness Michael I.,
Arrol Sharon,
Durrington Paul N.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80962-3
Subject(s) - paraoxonase , chemistry , low density lipoprotein , lipoprotein , atheroma , biochemistry , pon1 , thiobarbituric acid , lipid peroxidation , oxidative phosphorylation , high density lipoprotein , in vivo , enzyme , cholesterol , medicine , endocrinology , biology , microbiology and biotechnology , genotype , gene
Oxidative modification of low‐density lipoprotein (LDL) enhances its uptake by macrophages in tissue culture and in vivo may underly the formation of arterial fatty streaks, the progenitors of atheroma. We investigated the possible protection which high‐density lipoprotein (HDL) affords against LDL oxidation. The formation of lipoperoxides and thiobarbituric acid reactive substances when LDL was incubated with copper ions was significantly decreased by HDL. The enzyme, paraoxonase (E.C. 3.1.8.1), purified from human HDL, had a similar effect and thus may be the component of HDL responsible for decreasing the accumulation of lipid peroxidation products.