Premium
Functional differences in human neutrophils isolated pre‐ and post‐prandially
Author(s) -
Uhlinger David J.,
Burnham David N.,
Mullins Richard E.,
Kalmar John R.,
Cutler Christopher W.,
Arnold Roland R.,
Lambeth J.David,
Merrill Alfred H.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80933-t
Subject(s) - chemistry , neutrophile , immunology , biology , inflammation
Activated polymorphonuclear leukocytes have been associated with neoplasia, atherogenesis and reperfusion injury. Since some of these conditions are also correlated with dietary fat, we examined the functional characteristics of leukocytes isolated from subjects before and after consumption of a lipid‐rich meal. There was up to 2‐fold greater superoxide generation in response to agonists in leukocytes obtained post‐prandially; the maximum increase was observed about 4 h after eating and followed the peak (2–4 h) in serum triglycerides. Neutrophils isolated post‐prandially also exhibited impaired chemotaxis and defective bacterial killing, but normal phagocytosis. These findings provide a new variable that should be considered in studies of leukocytes.