Premium
Two types of linkage between codon usage and gene‐expression levels
Author(s) -
Nakamura Takeshi,
Suyama Akira,
Wada Akiyoshi
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80923-q
Subject(s) - codon usage bias , gene , genetics , biology , start codon , gene expression , escherichia coli , silent mutation , mutation , messenger rna , genome , missense mutation
The relation between codon usage and gene‐expression levels is an intensively investigated and discussed topic in the field of molecular evolution. We statistically analyzed 25 Escherichia coli gene sequences by a new classification of synonymous codons and found that (i) there are two distinct types of linkage between codon usage and gene‐expression levels in E. coli , and (ii) one of the two kinds of codon preferences (the codon preference concerned with interaction of GC/AT choice at three codon positions) is observed significantly in weakly expressed genes.