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Laminin A‐related domains in crb protein of Drosophila and their possible role in epithelial polarization
Author(s) -
Patthy László
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80917-r
Subject(s) - laminin , microbiology and biotechnology , drosophila (subgenus) , polarization (electrochemistry) , biology , chemistry , genetics , gene , extracellular matrix
It is shown that four domains of the integral membrane protein crb of Drosophila are homologous with five C‐terminal domains of the laminin A chain and merosin. Since the latter domains of laminin A have been implicated in determining epithelial polarity, the homology may suggest a similar function for these domains or crb. Such a function would be consistent with the known importance of crb for organization of epithelia in Drosophila .