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Protein kinase C activity in rat skeletal muscle Apparent relation to body weight and muscle growth
Author(s) -
Richter Erik A.,
Nielsen Niss B.S.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80913-n
Subject(s) - protein kinase c , medicine , plantaris muscle , muscle hypertrophy , endocrinology , basal (medicine) , skeletal muscle , soleus muscle , body weight , compensatory hypertrophy , chemistry , biology , kinase , biochemistry , insulin
Protein kinase C (PKC) may be involved in growth regulation. In the present study the relationship between body weight, and thereby age, and the activity of PKC in muscle as well as in rapidly growing overloaded muscle were investigated. PKC activity in music was linearly inversely correlated to rat weight in both soleus ( r = −0.59, P < 0.05) and in plantaris ( r = −0.74, P < 0.01) muscles. During compensatory hypertrophy. PKC activity per muscle was maximally increased compared with the contralateral control muscles after 4days in both soleus(126%)and in plantaris (105%) but had returned to basal levels by the 9th day. The data are in agreement with a role for PKC in muscle growth.