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A novel brain‐specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr‐Pro kinase (TPK II) from tau protein kinase fractions
Author(s) -
Takahashi Miho,
Tomizawa Kayoko,
Ishiguro Koichi,
Sato Kazuki,
Omori Akira,
Sato Showbu,
Shiratsuchi Akiko,
Uchida Tsuneko,
Imahori Kazutomo
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80903-g
Subject(s) - protein kinase a , olfactory bulb , cerebrum , biochemistry , cerebellum , kinase , phosphorylation , biology , microbiology and biotechnology , chemistry , central nervous system , endocrinology
A novel brain‐specific 25 kDa protein (p25) was purified from a bovine brain extract. The protein was phosphorylated by Ser/Thr‐Pro kinase (TPK II) in tau protein kinase fractions at the Ser residues of Ser‐Pro sequences. Using immunoblot analysis, the protein was found only in brain extracts, and was most abundant in the brain regions such as cerebrum and hippocampus, but less abundant in cerebellum, medulla oblongata and olfactory bulb. The protein was detected in rat, bovine and human brain extracts, indicating that this protein specifically exists in mammalian brain tissues.