Premium
Fibronectin is a non‐viral substrate for the HIV proteinase
Author(s) -
Manfred J. Oswald,
K. von der Helm
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80888-a
Subject(s) - retrovirus , in vitro , fibronectin , cytoskeleton , group specific antigen , chemistry , biochemistry , biology , microbiology and biotechnology , virus , virology , cell
The retrovirus encoded proteinase (PR) is required for the proper maturation of viral particles into infectious virus. The PR had been considered highly substrate specific, cleaving exclusively the viral gag and gag‐pol protein precursor. It has recently been reported, however, that cytoskeleton and other cellular filament proteins can be cleaved by the HIV‐1 PR. Here we have evidence that a cell‐associated protein, the fibronectin (A‐chain) is also cleaved in vitro specifically by this PR. The possibility of a cytotoxic role of the PR is conceivable.