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Increase of β‐actin mRNA upon hypotonic perfusion of perfused rat liver
Author(s) -
Wolfgang A. Schulz,
Peter Eickelmann,
Christian Hallbrucker,
Helmut Sies,
Dieter Häussinger
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80880-c
Subject(s) - glyceraldehyde 3 phosphate dehydrogenase , tonicity , messenger rna , albumin , tyrosine aminotransferase , actin , perfusion , cytoskeleton , chemistry , biology , biochemistry , endocrinology , microbiology and biotechnology , medicine , enzyme , cell , enzyme inducer , gene
β‐Actin mRNA levels in livers exposed to hypotonic perfusion (from 305 to 225 mosmol/1) for one hour are increased 2‐fold relative to albumin mRNA. Like albumin, glyceraldehyde‐3‐phosphate dehydrogenase and tyrosine aminotransferase mRNAs remain at the levels observed under normotonic conditions. The increase in β‐actin mRNA is interpreted as a cytoskeletal response due to cell swelling.