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The relaxin gene is located on chromosome 19 in the mouse
Author(s) -
Kerry J. Fowler,
W. M. Clouston,
R. E. K. Fournier,
Bronwyn A Evans
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80863-x
Subject(s) - relaxin , biology , gene , genetics , bamhi , recombinant dna , chromosome , restriction fragment length polymorphism , microcell , microbiology and biotechnology , genotype , receptor , computer science , operating system
Relaxin is a polypeptide hormone that exerts a variety of physiological effects during pregnancy. To investigate the possibility that known genetic mutations affecting aspects of reproductive physiology result in alterations in the structure or production of relaxin, we have determined the chromosomal location of the mouse gene. The finding of a Bam HI restriction fragment length polymorphism in AKR mice enabled us to use recombinant inbred strains to make an assignment to chromosome 19. This was confirmed by Southern analysis of DNA from microcell hybrids.