Premium
Inhibition of electron transport of rat liver mitochondria by unnatural (‐)‐antimycin A 3
Author(s) -
H Miyoshi,
H Kondo,
T Oritani,
I Saitoh,
H Iwamura
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80834-p
Subject(s) - antimycin a , chemistry , mitochondrion , electron transport chain , biochemistry
The inhibition of electron transport by unnatural (‐)‐antimycin A 3 was examined with rat liver mitochondria and compared with that of natural (+)‐antimycin A 3 . (−)‐Antimycin A 3 inhibited respiration about 1/100th as strongly as natural (+)‐antimycin A 3 . (−)‐Antimycin A 3 binding to the cytochrome bc 1 complex did not seem to induce a conformational change in this proteinous complex. The binding site of (−)‐antimycin A 3 was probably the same as that of (+)‐antimycin A 3 (at the Q i center). However, the mode of interaction with the Q i center by (−)‐antimycin A 3 and (+)‐antimycin A 3 was somewhat different.