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Signal transduction mechanism of interleukin 6 in cultured rat mesangial cells
Author(s) -
Fukunaga Megumu,
Fujiwara Yoshihiro,
Fujibayashi Mari,
Ochi Satoshi,
Yokoyama Kenji,
Ando Akio,
Hirano Toshio,
Ueda Naohiko,
Kamada Takenobu
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80813-i
Subject(s) - autocrine signalling , signal transduction , prostaglandin e2 , inositol phosphate , microbiology and biotechnology , mesangial cell , intracellular , endocrinology , chemistry , inositol , medicine , inositol trisphosphate , interleukin , cytokine , biology , receptor , biochemistry , kidney
Interleukin 6 (IL‐6) is one of the potent autocrine growth factors for mesangial cells. We investigated the signal transduction mechanism or IL‐6 in cultured rat mesangial cells. IL‐6 induced a transient increase of inositol 1,4,5‐trisphosphate (Ins 1,4,5‐P 3 ) followed by a transient and sustained increase of intracellular calcium concentration, suggesting that IL‐6 stimulates phosphoinositide turnover. IL‐6 also stimulated prostaglandin E 2 (PGE 2 ) production. The IL‐6‐concentration dependency in PGE 2 production was similar to that in Ins 1,4,5‐P 3 production. We concluded that the action of IL‐6 on mesangial cells is exerted at least partially through the enhancement of phosphoinositide turnover and PGE 2 production.